Botulinum toxin for chronic anal fissure after biliopancreatic diversion for morbid obesity

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Botulinum toxin for chronic anal fissure.

Botulinum toxin can chemically denervate striated muscle. Botulinum toxin A (15 U) was used to treat ten patients with chronic anal fissure by injection in the internal sphincter. In seven patients, the lesion healed at 2 months after treatment; one relapsed at 3 months. In one patient the lesion healed at 1 month, but partly relapsed a month later. Mild faecal incontinence lasting for 1 day wa...

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Botulinum toxin treatment for anal fissure.

OBJECTIVES To evaluate the effectiveness of Botulinum toxin injection in the treatment of anal fissure. METHODS 38 patients (22 males, 16 females; mean age (SD) of 33.3 (8.3) years) who have presented to Surgical Outpatient Clinic at Al Ain Hospital, United Arab Emirates, with anal fissure in the period between June 2000 and September 2001 and treated with Botulinum toxin injection were retro...

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Botulinum toxin promoted healing and relieved symptoms of chronic anal fissure.

Main results At 1 and 2 months, more patients allocated to botulinum toxin than to placebo had healed fissures (p=0.05 at 1 month and p=0.003 at 2 months) and symptomatic relief (p=0.003 for both 1 and 2 months follow up) (table). 4 patients who still had fissures were retreated with botulinum toxin, 25 U, and all achieved complete healing within 2 months of rescue treatment. No relapses occurr...

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Body contouring after biliopancreatic diversion.

BACKGROUND From Nov 2001 to Mar 2006, 176 patients underwent body contouring plastic surgery after prior biliopancreatic diversion (BPD). Weight loss had varied from 30-100 kg. The plastic surgery targeted the arms (24 patients), breast (58), abdomen (62) and thighs (20), plus torsoplasty (12). METHODS BPD is a "non-cosmetic" bariatric operation which results in malabsorption and subsequent m...

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Bilateral versus posterior injection of botulinum toxin in the internal anal sphincter for the treatment of acute anal fissure.

AIM Comparison of bilateral versus posterior injection of botulinum toxin into the internal anal sphincter for treatment of acute anal fissure. METHODS Forty patients with acute anal fissure were randomly divided into two equal groups. Group 1 was treated by injecting 20 units of botulinum toxin into each side of the internal anal sphincter, and group 2 by injecting 25 units of botulinum toxi...

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ژورنال

عنوان ژورنال: World Journal of Gastroenterology

سال: 2012

ISSN: 1007-9327

DOI: 10.3748/wjg.v18.i10.1021